Choosing A Peptide Synthesizer: Things You Must Consider

For each investigation, choosing the right peptide synthesizer can be challenging. When you want to do peptide synthesis, you should consider a synthesizer for it.

Synthesizers have the power to perform multi-compound synthesis easily and effectively. But only the purification of a single compound is carried out.

But before opting for a peptide synthesizer, there are several things that must be taken into account. These are:

Parallel synthesis and performance issue

In research, different phases and applications require different amounts of peptides. A peptide drug recovery program involves the detection of hundreds and thousands of peptides.

This helps optimize SAR. [Structure Activity Relationships] and focused libraries to detect a single candidate, which is quite advanced.

But to be successful it is necessary to opt for synthesizers that have reaction vessels. This is mainly because it can provide a level of parallel synthesis that you might need to match your application.

The synthesis scale

when for each peptide synthesisResearchers might need a different amount of peptide.

For example, the amount of peptide materials will be greatly increased when peptide therapy undergoes analysis at an early stage, leading to preclinical development and optimization.

In this case, using the right peptide synthesizer will help meet your needs and also provide you with flexibility throughout the process.

Find a partner to meet your peptide synthesis needs

For most production facilities and laboratories, a peptide synthesizer is extremely important. It will provide you with years of error-free operations and will also improve your team’s productivity.

On top of that, the synthesizer can provide much greater flexibility to meet current and anticipated needs. Therefore, when you have a limited budget or some changes need to be made to the pool, you should opt for a system that comes with additional capacity or features.

You should look for an instrumentation partner who can offer you the support you need to ensure you reach your goals on time.

Need for special chemistry

There are researchers who synthesize common linear peptides or could create cyclic peptoids, peptides and other peptidomimetics. There are some who work with Oligos, PMO and PNA.

For the synthesis of cyclic peptides, it is necessary to use reaction steps and protected amino acid derivatives for orthogonal cyclization and deprotection. The synthesis of “peptoids” and oligomimetics, PNAs and oligos may require unique reagents and monomers.

To make these molecules, experts will need an instrument that provides a high level of flexibility in terms of bottle positions and protocol. That is why many of the instruments use more than 40 amino acids instead of simply using only 20 positions for all natural amino acids.

Most of the reagents and monomers used for all of these specialty chemicals can be quite expensive. Many synths act as a great addition to ensure nothing is wasted.


The information in this post clearly tells you about the various things you need to consider when planning to use a synthesizer. Make sure you go through the points properly to have a good understanding.

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